In this work, we applied **supramolecular-template-assisted stratge** to fabricate **nano yolk-shell structures**. The idea is to wrap a **plasmonic core** in a dynamic polyphenol network, and fuse a second **polyphenol shell** on it. After template degradation, polyphenol shell creates a semi-soft cavity to host the core and additional cargos, while provides an highly-active interface to incoporate targeting peptide motifs. In this design, we integrated plasmonic (metal) and photosensitive (polyphenol) materials in a signle yolk-shell structure. Novolty of this partice includes **tunable nanomechanical properties** for enhanced photoacoustic imaging, photothermal transduction, and deep-tumor penetration.
Aromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these interactions can be replicated in an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co-assembly experiments with plasmonic gold and surfactant-like peptides (SLPs) spanning a wide range of aromatic residues, polar stretches, and interfacial affinities.
Using nanocrystals of insoluble drug as carriers, a carrier material-free platform was developed previously to deliver a second insoluble drug for codelivery. To extend the concept, we hypothesized, herein, that the platform allows for codelivery of hydrophobic and hydrophilic drugs using a cocrystalization-like strategy.
Using nanocrystals of insoluble drug as carriers, a carrier material-free platform was developed previously to deliver a second insoluble drug for codelivery. To extend the concept, we hypothesized, herein, that the platform allows for codelivery of hydrophobic and hydrophilic drugs using a cocrystalization-like strategy.
The rapid spread of **coronavirus disease (COVID-19)** has greatly disrupted the livelihood of many people around the world. To date, more than 35.16 million COVID-19 cases with 1.037million total deaths have been reported worldwide. Compared with China, where the disease was first reported, cases of COVID-19, the number of confirmed cases for the disease in the rest of the world have been incredibly high. Even though several dugs have been suggested to be used against the disease, the said interventions should be backed by empirical clinical evidence. Therefore, this paper provides a systematic review and a meta-analysis of **efficacy and safety** of different COVID-19 drugs.
Drug delivery strategies are potent to promote their delivery. Herein, we reviewed the potential targets for immunotherapy against the major inflammatory diseases, discussed the biologics and drug delivery systems involved in the immunotherapy, particularly highlighted the approved therapy tactics, and finally offer perspectives in this field.