Source Themes

Mutational analysis of a familial adenomatous polyposis pedigree with bile duct polyp phenotype

Submitted to **Canadian Journal of Gastroenterology and Hepatology**

The role of the novel lincRNA uc002jit.1 in NF-kB-mediated DNA damage repair in acute myeloid leukemia cells

The therapeutic potential of long noncoding RNAs (lncRNAs) in acute myeloid leukemia (AML) remains unclear. In this study, we identified a novel lncRNA and indicated that it may be associated with the treatment of AML and could be a new biomarker and therapeutic target for AML.

Analysis of mutations in six Chinese families with autosomal dominant polycystic kidney disease

Clinical data and genetic features of six Chinese families including ADPKD patients were analyzed via Next generation sequencing (NGS), Sanger sequencing, and multiplex ligation-dependent probe amplification.

“Locked” cancer cells are more sensitive to chemotherapy

Conventional chemotherapy can kill the cancer cells and, whereas, would exacerbate the metastasis and drug resistance. Here, a new combinatorial treatment strategywas probed via dosing dual nanomedicines, marimastat‐loaded thermosensitive liposomes (MATT‐LTSLs) and paclitaxel nanocrystals (PTX‐Ns).